Kazakova, A.; Frydrych, I.; Jakubcová, N; Pokorný. J.; Lišková, B.; Gurská, S.; Džubák, P.; Hajdúch, M.; Urban, M.
Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells – Synthesis, potency, and mitochondrial mechanism of action
Eur. J. Med. Chem. 2024, 269 (N/A), 116336. DOI: 10.1016/j.ejmech.2024.116336
Borková, L.; Frydrych, I.; Vránová, B.; Jakubcová, N.; Lišková, B.; Gurská, S.; Džubák, P.; Pavliš, P.; Hajdúch, M.; Urban, M.
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes
Eur. J. Med. Chem. 2022, 244 (N/A), 114850. DOI: 10.1016/j.ejmech.2022.114850
Hodoň, J.; Frydrych, I.; Trhlíková, Z.; Pokorný, J.; Borková, L.; Benická, S.; Vlk, M.; Lišková, B.; Kubíčková, A.; Medvedíková, M.; Pisár, M.; Sarek, J.; Das, V.; Ligasová, A.; Koberna, K.; Džubák, P.; Hajdúch, M.; Urban, M.
Triterpenoid pyrazines and pyridines – synthesis, cytotoxicity, mechanism of action, preparation of prodrugs
Eur. J. Med. Chem. 2022, 243 (N/A), 114777. DOI: 10.1016/j.ejmech.2022.114777
Chasák, J.; Šlachtová, V.; Urban, M.; Brulíková, L.*
Squaric acid analogues in medicinal chemistry
Eur. J. Med. Chem. 2021, 209 (-), 112872 (1-23). DOI: 10.1016/j.ejmech.2020.112872
Urban, M.; Šlachtová, V.; Brulíková, L.*
Small organic molecules targeting the energy metabolism of Mycobacterium tuberculosis
Eur. J. Med. Chem. 2021, 212 (-), 113139 (1-17). DOI: 10.1016/j.ejmech.2020.113139
Gonzalez, G.; Hodoň, J.; Kazakova, A.; D’Acunto, C. W.; Kaňovský, P.; Urban, M.; Strnad, M.
Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models
Eur. J. Med. Chem. 2021, 213 (n/a), 113168. DOI: 10.1016/j.ejmech.2021.113168
Bachořík, J.; Urban, M.
Biocatalysis in the Chemistry of Lupane Triterpenoids
Molecules 2021, 26 (8), 2271(1-26). DOI: 10.3390/molecules26082271
Pokorný, J.; Olejníková, D.; Frydrych, I.; Lišková, B.; Gurská, S.; Benická, S.; Šarek, J.; Kotulová, J.; Hajdúch, M.; Džubák, P.; Urban, M.
Substituted dienes prepared from betulinic acid – Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters
Eur. J. Med. Chem. 2021, 224 (n/a), 113706(1-18). DOI: 10.1016/j.ejmech.2021.113706
Borková, L.; Frydrych, I.; Jakubcová, N.; Adámek, R.; Lišková, B.; Gurská, S.; Medvedíková, M.; Hajdúch, M.; Urban, M.
Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid
Eur. J. Med. Chem. 2020, 185 (N/A), Article Number: UNSP 111806 (1-18). DOI: 10.1016/j.ejmech.2019.111806
Spáčilová, P.; Kvasnica, M.; Urban, M.; Hajdúch, M.; Šarek, J.
2‑Deoxyglycoside Conjugates of Lupane Triterpenoids with High Cytotoxic Activity – Synthesis, Activity, and Pharmacokinetic Profile
Bioconjugate Chem. 2019, 30 (11), 2844-2858. DOI: 10.1021/acs.bioconjchem.9b00565